منابع مشابه
Macrolides and pneumonia.
Community acquired pneumonia (CAP) is increasing in incidence, and is presently responsible for about 1% of emergency medical admissions with an associated mortality of between 5% and 24%. Improving the outcome of CAP is, therefore, a major health priority, but what is the best method to do this? Many audits have shown poor adherence to national guidelines for the management of CAP, with the in...
متن کاملMacrolides and community-acquired pneumonia: is quorum sensing the key?
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing...
متن کاملMethacholine and Macrolides
study are relevant, I believe that the design of the study was not adequate to answer these questions. First, all patients were on NM for w3 months and one patient even for 70 months, whereas they trained only for 1 day on FFM. In our centre (Dept of Pulmonary Diseases/ Home mechanical ventilation, University Hospital Groningen, Groningen, The Netherlands), patients routinely need more time (y7...
متن کاملMacrolides: pharmacokinetics and pharmacodynamics.
Three pharmacokinetic/pharmacodynamic parameters--(i) the peak concentration to the minimum inhibitory concentration ratio (C(max)/MIC); (ii) the area under the concentration-time curve to MIC ratio (AUC(24h)/MIC); and (iii) the time the concentration exceeds the MIC (T>MIC)--are important predictors of the clinical efficacy of antibiotics. For antibiotics with pronounced concentration-dependen...
متن کاملMacrolides in dermatology
Erythromycin was the first macolide discovered in 1952. In 1990s new macrolides including clarithromycin, azithromycin, and dirithromycin were introduced to the market. We provide a review of their structure, pharmacokinetics, mechanisms of action, and indications in dermatology.
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ژورنال
عنوان ژورنال: Thorax
سال: 2013
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2012-202425